AIRE and hyperinsulinemic hypoglycemia, familial, 4: In addition, both decreased frequencies and impaired suppressive function in Tregs were associated with specific defects in the peripheral B cell tolerance checkpoint in patients with deficiency in autoimmune regulator (AIRE), lipopolysaccharide-responsive and beige-like anchor protein (LRBA), dedicator of cytokinesis 8 (DOCK8), or Wiskott-Aldrich syndrome protein (WASP), which suggests that the expansion of autoreactive B cells in the periphery is suppressed by Tregs (19, 21–23).