Top correlates with α score in T1D (Figure 5A and Supplemental Table 4) included proteasomal components (PSMA6, PSMB6, PSMF1, PSMD12, PSMD7, and PSMC3), suggesting that canonical cell behavior in T1D may rely on higher proteasomal activity, likely associated with alleviating ER stress and unfolded protein responses (24). The gene discussed is PSMA6; the disease is type 1 diabetes mellitus.