Top correlates with α score in T1D (Figure 5A and Supplemental Table 4) included proteasomal components (PSMA6, PSMB6, PSMF1, PSMD12, PSMD7, and PSMC3), suggesting that canonical cell behavior in T1D may rely on higher proteasomal activity, likely associated with alleviating ER stress and unfolded protein responses (24). This evidence concerns the gene PSMC3 and type 1 diabetes mellitus.