Expectedly, negative correlates with α score were MHC-I antigen presentation (B2M, HLA-B, HLA-C) and the α cell transcription factor (TF) ARX (Aristaless Related Homeobox) with its enhancer FOXO1 (58) (Forkhead Box O1), previously associated with α cell dysfunction in T2D (25). The gene discussed is FOXO1; the disease is type 2 diabetes mellitus.