This study also highlighted the role of ATF6 (\documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{mathrsfs}\usepackage{upgreek}\setlength{\oddsidemargin}{-69pt}\begin{document}$$\downarrow$$\end{document}rs10918270)), so the elucidation of the inhibitory mechanism of alpha-synuclein on ATF6 signaling enhances our comprehension of the involvement of ER stress and the unfolded protein response in PD. Here, SNCA is linked to Parkinson disease.