The causal relationship between higher cathepsins H levels and decreased risk of pancreatic cancer (IVW: p = 0.0160, OR = 0.8851, 95%CI = 0.8025–0.9773) were steadily observed, which were corroborated by the MR-Egger method (p = 0.0110, OR = 0.8799, 95%CI = 0.7969–0.9714). The gene discussed is CTSH; the disease is pancreatic neoplasm.