The specific roles of bEV in colorectal cancer include: simultaneously reducing the gene expressions of E-cadherin and cadherin-1 and promoting genotype alterations similar to epithelial-mesenchymal transition in tumor cells [132]; inducing IL-8 expression and forming a pro-inflammatory microenvironment conducive to tumor growth [133], these factors act together and ultimately promote the migration and invasion of cancer cells in the body [134]. The gene discussed is CDH1; the disease is neoplasm.