ASCL1 and cancer: TME stratification, based on pan‐cancer microenvironment subtypes51 and pan‐cancer immune subtypes49 (Figure S10B‒F), revealed stark differences: KC1 tumours were predominantly classified as immune‐depleted (D phenotype) subtype, characterised by negligible immune infiltration, suggesting a poor response to ICIs (Figure S10B), consistent with ASCL1‐mediated immune evasion.31