In order to reduce kidney damage, this might result in novel therapeutic strategies and ideas for treating AKI and the AKI to CKD transition pathway.108 MiR-146a-3p generated from serum exosomes improved macrophage M2 polarization in allergic rhinitis by targeting VAV3 via the PI3K/AKT/mTOR pathway. This evidence concerns the gene VAV3 and chronic kidney disease.