Intermittent fasting(IF), as a lifestyle strategy, has been shown to enhance mitochondrial function and improve insulin sensitivity, along with reducing cardiovascular risk factors in a diet-controlled environment.6,7 The metabolic shifts induced by IF increase metabolism and lifespan,8 contributing to reduced insulin resistance and obesity.9–11 In addition, IF has shown potential in improving both blood glucose control and bone health in diabetic osteoporosis patients. The gene discussed is INS; the disease is Insulin resistance.