DLGAP2 and Alzheimer disease: Therefore, in this study, we set out to test whether viral‐mediated overexpression of DLGAP2 in the hippocampus would improve cognitive outcomes in the 5XFAD.D2F1 mouse strain with the highest polygenic risk score for human AD as well as being associated with lower cognitive resilience to AD in mice6, 7 and better understand the mechanisms in which DLGAP2 may modify cognition and synaptic form/function.