Established risk factors encompass inherited thrombophilias (e.g., protein C/S deficiencies, factor V Leiden mutation, plasminogen activator inhibitor-1 (PAI-1) polymorphisms, and prothrombin G20210A mutation), acquired hypercoagulable states (antiphospholipid syndrome, pregnancy/puerperium, hormonal therapies), infections, malignancy, and trauma [2]. The gene discussed is SERPINE1; the disease is infection.