IDH2 and neoplasm: Although metabolite estimation depends on many assumptions that are used in calculating the concentrations, tumors with 2HG > 1.0 mM in the present study can be presumed to harbor an IDH1 or IDH2 mutation, and patients with 2HG < 1.0 mM may be IDH wildtype or could have low cellularity IDH‐mutant tumor.