FOS and obesity due to melanocortin 4 receptor deficiency: Our observations align with recent findings by Liang et al., identifying c‐Fos as a negative regulator of hepatocyte maturation in organoid models, where Fos knockout promoted hepatocyte differentiation.[28] The chronic activation of stress pathways, including c‐Fos, in obesity not only impairs metabolic homeostasis but may also create a pro‐tumorigenic environment through persistent metabolic and inflammatory signaling.