Hepatocyte metabolic reprogramming and inflammation driven by c‐Fos have been linked to liver disease and to the initial steps of HCC in mouse models.[15] To examine c‐Fos expression in established HCC, we administered diethyl nitrosamine (DEN) to 2‐week‐old male mice, which were subsequently fed a 37‐week chow diet (Figure S6A, Supporting Information) or a 25‐week HFHFHCD (Figure S6C, Supporting Information), respectively. This evidence concerns the gene FOS and hepatocellular carcinoma.