Previously, it has been proposed that HLA‐G expression in malignant tumors is a means of escaping host immune attack,[19] and a recent meta‐analysis showed that HLA‐G expression was associated with reduced survival in various solid tumors.[20] However, specific roles of HLA‐G and/or HCG in vascular or lymphatic invading cancer cells in the distant metastasizing phase has not been observed. Here, HLA-G is linked to cancer.