In lung cancer, CXCR4 plays a key role in the spread of metastatic cells to the lymph nodes, while in pancreatic cancer, CXCR4 and CXCR2 are involved in mediating tumor-induced inflammation, which creates a favorable microenvironment for tumor cell survival and spread [37, 38]. Here, CXCR4 is linked to pancreatic neoplasm.