In breast cancer, Du et al. believe that the co-expression of LAG3 and PD1 is closely related to the inhibition of T cell secretion function [36, 37], while others suggest that the high expression of LAG3 is closely related to the increase in NK and DC cells in breast cancer, lung adenocarcinoma, and LUSC [38]. Here, LAG3 is linked to lung adenocarcinoma.