Our previous study demonstrated that FGL1 downregulation in lung adenocarcinoma prevents Jurkat T cell apoptosis, and accelerates TNF-α secretion [22], suggesting an FGL1-related immune mechanism as a potential cause of N2 lymph node metastasis in T1 NSCLC via FGL1-mediated immune escape of CCNE1(+) Cells. Here, TNF is linked to lung adenocarcinoma.