RORB and Alzheimer disease: In the human brain cortex, the earliest areas affected by AD pathology are the entorhinal cortex and transentorhinal cortex, followed by the hippocampal CA1 region [89] Several neuronal subtypes have been reported to be particularly vulnerable in AD [89–92] One population of excitatory neurons in the entorhinal cortex that express RORB is also enriched for genes encoding axon-localized proteins and voltage-gated potassium channels [93].