Tenuigenin also inhibited epithelial cell oxidation and senescence through the Sirtuin 1/peroxisome proliferators-activated receptor γ (PPAR-γ) coactivator 1 alpha pathway, alleviating pulmonary fibrosis [19], and protected against Staphylococcus aureus-induced pneumonia in mice [11]. Here, SIRT1 is linked to pulmonary fibrosis.