The ability of TEXs to suppress anti-tumor immunity and promote immune evasion mainly consists of (1) carrying immunosuppressive PD-L1 on their surface and suppressing activated T cells (2) reprogramming tumor-infiltrating immune cells to an immunosuppressive phenotype (3) inhibiting NK cell function (4) promoting metastatic niches by recruiting and educating immune cells [128]. The gene discussed is CD274; the disease is neoplasm.