A few years ago, David Novo et al. found that exosomes produced by tumor cells expressing mutant p53 (mutp53) mediate the invasive/migratory acquisition of mutp53 in intercellular transfer by increasing Rab-coupling protein (RCP)-dependent integrin cycling in other tumor cells, and also affect integrin in normal fibroblasts transport to promote the deposition of pro-invasive ECM rich in the pro-invasive microenvironment [148]. The gene discussed is TP53; the disease is neoplasm.