To pinpoint more precisely which would be the involvement of RECQL4 and BLM helicases to cell death process, we employed WP744, a 4’-O-benzylated doxorubicin analogue, which induces the apoptotic, p53-dependent cell death in many tumor cells, including glioblastoma cells [16, 25]. This evidence concerns the gene TP53 and glioblastoma.