In the setting of STEMI, a series of pathophysiological process, such as reduced cardiac output, systemic congestion, the activation of systemic vasoconstriction, diuretics use, and the administration of contrast media during revascularization could impair renal function [20], which in turn, aggravates cardiac dysfunction via activation of renin-angiotensin-aldosterone system (RAAS) and finally CRS develops with a vicious cycle between renal and cardiac dysfunction [9]. Here, REN is linked to congenital rubella syndrome.