TCF7L2 and Intellectual disability: Furthermore, several downregulated genes relate to brain development and intellectual disability, including BMP3, EBF2, EMX1, EOMES, LXH5, NHLH1, and UNCX. In addition, neural-related genes that were significantly upregulated include CNP, which is involved in neurogenesis; TCF7L2, which plays a role in WNT signalling during neural cell differentiation; and ZDBF2, which is regulated during the development of the hypothalamic-pituitary-adrenal axis.