Thus, to further specify that PSPC1 ubiquitination is regulated by CASC19 expression, we overexpressed CASC19 in HPNE cell line where basal CASC19 expression is less than any pancreatic cancer cells and it was found that the amount of ubiquitinated PSPC1 was less in CASC19 overexpressed HPNE cells (Supplementary Figure-S2). This evidence concerns the gene PSPC1 and familial pancreatic carcinoma.