CASC19 was also found to regulate global transcriptome of pancreatic cancer cells, affecting pathways like TGF-β signaling pathway, β-Catenin-TCF complex assembly, etc. CASC19 was localized to nucleus of pancreatic cancer cells and was identified to interact with PSPC1, a metastatic reprogramming protein. This evidence concerns the gene HNF4A and familial pancreatic carcinoma.