CD4 and non-small cell lung carcinoma: Similarly, Treg signaling was found to trigger the GATA binding protein 3/Nitric oxide synthase 2 (GATA3/NOS2)-associated immunosuppression by inhibition of the stimulator of interferon genes (STING) pathway—which blocks CD4+ T infiltration—in NSCLC tissues, thereby promoting pre-metastatic niche development and increasing lung metastatic burden [542].