Moreover, highly proliferative tumor necrosis factor receptor 2 positive (TNFR2+) Tregs with overexpression of CTLA-4 molecules were also detected in the peripheral blood and pleural effusions, and were assumed to mediate stronger immunosuppression than TNFR2− Tregs in NSCLC patients [552, 553]. Here, TNFRSF1B is linked to Pleural effusion.