Likewise, M2-type TAMs were found to upregulate CRYAB (alpha-crystallin B chain, a member of the small heat shock protein superfamily) expression on Lung cancer cells and activate the extracellular regulated kinase 1/2 (ERK1/2)/Fos-related antigen 1 (Fra-1)/Slug pathway linked to the EMT process, resulting in an enhanced NSCLC cell invasion and migration [330]. The gene discussed is CRYAB; the disease is non-small cell lung carcinoma.