Similarly, interleukin 6 (IL-6) released by M2-type TAMs enhances the cyclooxygenase-2 (COX-2) and prostaglandin E2 (PGE2) expression in cancer cells, which has been demonstrated in promoting the nuclear translocation of β-catenin and stimulating EMT in NSCLC cell lines [320]. This evidence concerns the gene PTGS2 and cancer.