Therefore, additional biomarkers have been identified that exhibited high potential in distinguishing the ADC and SCC subtypes of NSCLC, including melanophilin (MLPH), desmoglein 3 (DSG3), desmocollin 3 (DSC3), keratin 5 (KRT5), keratin 6 A (KRT6A), keratin 6B (KRT6B), surfactant-associated protein A2 (SFTA2), surfactant-associated protein A3 (SFTA3), calmodulin-like protein 3 (CALML3), and Transmembrane channel-like protein 5 (TMC5) [39, 40]. Here, DSC3 is linked to non-small cell lung carcinoma.