CXCR4 and non-small cell lung carcinoma: Moreover, CSCs co-express C-X-C Chemokine receptor Type 4 (CXCR4) and ecto-5'-nucleotidase (CD73, also known as NT5E–5'-Nucleotidase, Ecto) were found augmented in LNM compared to primary NSCLC, suggesting that the cells with the potential to originate metastasis may carry a potential immunosuppressive activity [356].