KRAS and non-small cell lung carcinoma: For example, KRAS and LKB1/STK11 mutations in NSCLC subtypes are associated with impaired T cell infiltration [705, 706], while EMT has been particularly shown to regulate the PD-L1 expression via epigenetic reprogramming, allowing NSCLC cells to escape immune surveillance [316]. Inactivation of the STK11 gene has been reported to weaken innate immune response by suppressing the stimulator of interferon genes (STING) pathway through epigenetic mechanisms [707].