Some of this is explained by association with somatic genetic variants in genes TLX1 and CDH1 (Additional File 1: Fig. S12); the latter is a known risk gene in hereditary diffuse gastric cancer and hereditary breast cancer [96–99], and it is tempting to speculate that NMD has a mediating role in this [100]. This evidence concerns the gene TLX1 and Hereditary breast cancer.