Typical of MMR-proficient colorectal adenocarcinomas (and adenomas) in general [5], APC was mutant in all tumors but one (colorectal carcinoma of individual III.6 from HNPCC20), and KRAS, too, was frequently affected (Fig. 4; Supplementary Table 3). The gene discussed is APC; the disease is colorectal adenocarcinoma.