BRAF and malignant peripheral nerve sheath tumor: We therefore assessed the in vitro efficacy of a potent and selective inhibitor of BRAF and CRAF― LXH254 (Monaco et al. 2021) on a panel of ten MPNST cell lines, including both widely available traditional cell lines as well as JH patient-derived lines that represent the genomic diversity of MPNST (Fig. 2E).