In PDX JH-2–002, the combination significantly repressed tumor mitotic activity and proliferation as indicated by mitotic counts and Ki-67 decrease (Fig. 6C-D) and markedly inhibited p-ERK, DUSP6 and several other downstream effectors (p-RSK, p-S6, p-RB, Cyclin D1) (Figs. 6C, 6E, 6F, S6A-C). The gene discussed is RB1; the disease is neoplasm.