These results confirmed the critical role of CRAF in NF1 biology and demonstrated that either genetic depletion of CRAF/BRAF (but not ARAF) or pharmacological inhibition using type 2 RAFi impaired the growth of NF1-MPNST cells, underscoring the role of CRAF/ BRAF as potential targets for NF1-MPNST. The gene discussed is NF1; the disease is malignant peripheral nerve sheath tumor.