PTPN11 and malignant peripheral nerve sheath tumor: We have recently reported that the adaptive response to MEKi in MPNST involves the upregulation of activity of multiple receptor tyrosine kinases (RTK) and the adaptor protein SHP2; and also, have demonstrated that combined inhibition of MEK and MET, or MEK and SHP2 is additive in both in vitro and in vivo models of NF1-MPNST (Wang et al. 2021; Wang et al. 2020).