The multi-mode galectin-3 actions in cancer promotion is known to derive largely from its versatile ability to interact with various galactose-terminated glycans carried on many cell surface and basement matrix molecules such as growth factor receptors, death receptors, adhesion molecules and immune check-point molecules (Barrow et al. 2011a; Marino et al. 2023; Liu and Rabinovich 2005). Here, LGALS3 is linked to cancer.