Many cell surface molecules and basement matrix proteins e.g. growth factor receptors, adhesion molecules and death receptors (Barrow et al. 2011a; Zhao et al. 2010; Kouo et al. 2015; Pang et al. 2022; Reticker-Flynn and Bhatia 2015), have been reported to carry galactose-terminated N- or O-linked glycans and are involved in galectin-3-mediated cancer promotion and immune cell activities. Here, LGALS3 is linked to cancer.