These results together suggest that PSEN1 SUMOylation may also contribute to the observed memory-rescuing effect and amyloid plaque-reducing effect of Lenti-EGFP-SUMO1 transduction to APP/PS1 mice, but it does not affect the results of decreased association between APP and BACE1 and increased BACE1 degradation upon APP SUMOylation. This evidence concerns the gene APP and amyloidosis.