In the present study, we have adopted the APP/PS1 transgenic mice as the animal model for AD, it is possible that the observed memory-rescuing effect and amyloid plaque-reducing effect of Lenti-EGFP-SUMO1 transduction to APP/PS1 mice could partly due to SUMOylation of PSEN1 (PS1) in addition to SUMOylation of APP. This evidence concerns the gene PSEN1 and Alzheimer disease.