These results together suggest that PSEN1 SUMOylation may also contribute to the observed memory-rescuing effect and amyloid plaque-reducing effect of Lenti-EGFP-SUMO1 transduction to APP/PS1 mice, but it does not affect the results of decreased association between APP and BACE1 and increased BACE1 degradation upon APP SUMOylation. Here, BACE1 is linked to amyloidosis.