Furthermore, CCND1 also demonstrated a significant association with the progression of dental caries (odds ratio = 1.15564, 95% CI 1.05554-1.26523, p = 0.0018), while SLC6A4, CASP3, NR3C1, and ANXA1 were linked to diseases of the pulp and periapical tissues. This evidence concerns the gene ANXA1 and dental caries.