MAPT and Alzheimer disease: All p-tau variants analyzed displayed much more dramatic increases in AD compared with controls, with + 4,549% increases for p-tau181 (p = 0.0008, Fig. 2I), + 791% for p-tau205 (p = 0.001, Fig. 2J), + 50,366% for p-tau217 (p = 0.0003, Fig. 2K), and + 11,405% for p-tau231 (p = 0.0008, Fig. 2L).