To assess the tumor-killing effect of IDR CAR-Ts toward CD19low cancer cells in vivo, CD19low Raji B cells expressing a luciferase reporter were injected into the immune-deficient NSG (NOD.Cg-PrkdcscidIl2rgtm1Wjl/SzJ) mice intravenously. The gene discussed is CTSG; the disease is cancer.