To delineate the role of NFATc1 in regulating Orai3 expression and function, we chose six human pancreatic cancer cell lines: MiaPaCa-2 and BxPC-3 (non-metastatic), PANC-1 and AsPC-1 (invasive), and CFPAC-1 and SW1990 (metastatic). Here, ORAI3 is linked to familial pancreatic carcinoma.