ORAI3 and pachyonychia congenita: This study has identified MARCH8 as a critical regulator of Orai3, which we had earlier reported as a driver of PC metastasis (Arora et al, 2021) Although MARCH8 E3 ubiquitin ligase has been studied in some cancer types (Singh et al, 2017; Fan et al, 2017; Wang et al, 2022b; Chen et al, 2021), its role in PC remains largely unappreciated.