LCNECs are considered intermediate entities between NSCLC and SCLC, harboring frequent LUAD-associated genomic alterations, but exhibiting NE features.45,106 Interestingly, recent molecular characterizations of these rare tumors converge into a classification driven by genomic events, which distinguishes SCLC-like LCNEC, enriched for RB1 mutations, and NSCLC-like LCNEC, enriched for STK11 and KEAP1 mutations. The gene discussed is KEAP1; the disease is non-small cell lung carcinoma.