KCNA3 and myeloid sarcoma: Having established that activated T cells from MS patients strongly upregulate Kv1.3 expression and pathological effector T cells are characterized by high basal mitochondrial ROS levels, we sought to determine their susceptibility to PAPTP-induced changes in mitochondrial parameters (changes in membrane potential and ROS release) and to apoptosis using flow cytometry (Fig. 1C).