Consistent with this, ShK has been reported to be less effective than PAPTP in EAE-AT (Beeton et al, 2001b), whereas transient application of PAP-1, a BBB permeable Kv1.3 inhibitor, has been shown to enhance optic nerve axonal damage in the MOG-induced rat EAE model (Stokely et al, 2008). Here, MOG is linked to ataxia telangiectasia.