Through bioinformatic technologies, our research indicates that 10 HUBgenes (ZNF595, PLXDC1, FNBP1L, KLRB1, NRCAM, PPCDC, C9orf139, SIGLEC17P, RRAS2 and DPRXP4) are significantly associated with IDD, providing more evidence about the vital role of ZNF595 and RRAS2 in IDD. Here, RRAS2 is linked to intervertebral disk degenerative disorder.