Through bioinformatic technologies, our research indicates that 10 HUBgenes (ZNF595, PLXDC1, FNBP1L, KLRB1, NRCAM, PPCDC, C9orf139, SIGLEC17P, RRAS2 and DPRXP4) are significantly associated with IDD, providing more evidence about the vital role of ZNF595 and RRAS2 in IDD. This evidence concerns the gene PLXDC1 and intervertebral disk degenerative disorder.