Future studies should also further investigate how different types of neurodegenerative disease (e.g. Alzheimer’s disease versus frontotemporal dementia) specifically map onto these patterns of expansion and compression, as well as the impact of age- and disease-related pathology (e.g., amyloid-beta, tau, TDP-43)50,51. The gene discussed is TARDBP; the disease is neurodegenerative disease.