Future studies should also further investigate how different types of neurodegenerative disease (e.g. Alzheimer’s disease versus frontotemporal dementia) specifically map onto these patterns of expansion and compression, as well as the impact of age- and disease-related pathology (e.g., amyloid-beta, tau, TDP-43)50,51. This evidence concerns the gene MAPT and early-onset autosomal dominant Alzheimer disease.