IFNG and COVID-19: Differential splicing at rs10735079 (chr12:112942203 G > A) leads to exon skipping between ENST00000452357 and ENST00000202917, with this SNP forming the most likely causal variant for both post-IFN-γ gQTL, tQTL and severe COVID-19 susceptibility (PPH4 = 0.99) (Fig. 3c–e), demonstrating multifaceted regulatory activity at this locus in a disease-relevant state.