Finally, our coculture method based on using hiPSC-derived as APCs has the potential to advance the understanding of pathogenic CD8+ T cells in neurological autoimmune diseases, paving the way for significant insights into this intricate field, and suggests that hiPSC-derived somatic cells could be used as antigen-presenting cells to study a large variety of other autoimmune diseases. Here, CD8A is linked to autoimmune disorder of the nervous system.