Considering that BAP31 is indispensable for regulating ER stress-mediated apoptosis in PD and can be phosphorylated by PINK1 at Ser142, we first overexpressed PINK1 and knocked down BAP31 in PC12 cells to assess the effect on ER stress- and apoptosis-related protein expression in PD. Here, PINK1 is linked to Parkinson disease.