Numerous proteins associated with PD, including alpha-synuclein (α-syn), Parkin RBR E3 ubiquitin-protein ligase (Parkin), PTEN-induced putative kinase 1 (PINK1), and DJ-1, are localized in MAMs and alter ER-mitochondria association [13–16]. This evidence concerns the gene PARK7 and Parkinson disease.