Among the interesting synapse-related genes showing differential changes in DD/ID- versus non-DD/ID-associated SCHEMA mutants were Atp2b2 (a calcium pump with emerging genetic association with bipolar/SCZ [48]), Gabrg2 (a GABA-A receptor subunit), and neurexin 1 (Nrxn1, deletions of which are associated with schizophrenia [49]) (Fig. 4D, Supplemental Table 2). This evidence concerns the gene NRXN1 and schizophrenia.