Because the thalamus is involved in sleep regulation [50] and sleep disturbances are a common feature of schizophrenia [51], we additionally examined the “circadian rhythm” gene set and found that it also showed this divergence, with significant upregulation in the non-DD/ID SCHEMA mutants, a trend to downregulation in the DD/ID-associated SCHEMA mutants, and significant downregulation in the Grin2b+/− mutant (Fig. 4B). Here, GRIN2B is linked to schizophrenia.