This convergent transcriptomic phenotype in the thalamus among non-DD/ID SCHEMA genes, and to a lesser extent Grin2a, may point to thalamic disturbances that are more specific to schizophrenia or psychosis spectrum disorders (Sp4 and Akap11 are also associated with bipolar disorder) than with severe neurodevelopmental disorders such as DD/ID/ASD. The gene discussed is SP4; the disease is bipolar disorder.