DRD1 and schizophrenia: Of particular interest, the Srrm2+/− and Dagla+/− mutants had a significant (FDR < 0.05) upregulation of the “response to dopamine” gene set in the striatum, including increased expression of Drd1 and Drd2 (Fig. 2B, C), which are dopamine receptors highly relevant to schizophrenia [34].