By integrating the top features from LASSO, RF, and SVM, six hub genes- NAMPT, SAT1, FASN, CISD2, LACTB, and PRNP were recognized and these findings suggest that the hub genes not only participate in regulating oxidative stress and inflammation but also serve potentially serve as biomarkers and therapeutic targets for RA. Here, CISD2 is linked to rheumatoid arthritis.