Although endothelium‐dependent vasorelaxation was not directly assessed in our study, eNOS knockout mice displayed hypertension due to the lack of vascular relaxation (Atochin and Huang 2010), whereas NMN‐treated aged mice exhibited improved aortic endothelial NO‐mediated vasodilation (Tarantini et al. 2019). This evidence concerns the gene NOS3 and hypertensive disorder.