Additionally, sirtuins may contribute to the hemodynamic dysregulation observed in VeNKO mice, as endothelial cell‐specific Sirt6 knockout mice exhibited elevated BP following Ang‐II administration and increased left ventricular hypertrophy and arterial thickening under desoxycorticosterone acetate/salt treatment (Guo et al. 2019). The gene discussed is AGT; the disease is left ventricular hypertrophy.