It was also found that the demethylcurcumin acted as a radical scavenger and/or inducer to elevate antioxidant defense systems in 6-OHDA-treated SH-SY5Y neuronal cells to reduce cell death, and exhibited anti-AChE activities and anti-Aβ aggregations in vitro and improved learning behaviors in scopolamine-induced amnesia ICR mice evaluated by passive avoidance and Morris water maze (Liu et al. 2020), which the DC-95EE and compound 2 (schafoside) exhibited the similar above-mentioned activities. This evidence concerns the gene ACHE and amnesia.