The corresponding rCBF pattern, dissimilar from the nAChR topography, comprised of relative decreased perfusion in temporal, occipital, parietal, medial frontal and anterior cingulate areas with relative increased perfusion in cerebellum, lentiform nucleus, central, thalamus, olfactory and orbitofrontal regions; a pattern similar to that observed in our previous rCBF assessment of DLB (in an independent cohort) [7]. The gene discussed is CHRNA4; the disease is Lewy body dementia.