WFS1 and Hodgkins lymphoma: While some HL genes such as TECTA and WFS1 have ethnic-based differences (Walls et al. 2020), they are not observed for GSDME. The c.991–6 C > G and c.990 + 503_990 + 1691delins132 variants were both observed in large Dutch families (Bischoff et al. 2004) and demonstrate results consistent with complete loss of splicing causing more severe HL (Supplementary Fig. S3).