While some HL genes such as TECTA and WFS1 have ethnic-based differences (Walls et al. 2020), they are not observed for GSDME. The c.991–6 C > G and c.990 + 503_990 + 1691delins132 variants were both observed in large Dutch families (Bischoff et al. 2004) and demonstrate results consistent with complete loss of splicing causing more severe HL (Supplementary Fig. S3). This evidence concerns the gene TECTA and Hodgkins lymphoma.