Regarding anticancer properties, geniposide has the ability to dramatically suppress the growth of a number of cancer cell lines, including oral squamous cell carcinoma cells [7,8], hepatocellular carcinoma cells [9], diffuse large B-cell lymphoma cells [10], medulloblastoma cells [11], gastric MKN45 cells [12], etc., mainly through the PI3K-Akt signaling pathway connected to apoptosis. The gene discussed is PIK3CA; the disease is oral cavity squamous cell carcinoma.