BCR and diffuse large B-cell lymphoma: Furthermore, m6A demethylase ALKBH5, is frequently enhanced in human diffuse large B-cell lymphoma (DLBCL, the most common and aggressive form of non-Hodgkin lymphoma) samples directly demethylates BCR signature transcripts, hijacking the post-transcriptional/translational regulation of gene expression, which is crucial for normal B-cell development and lymphomagenesis [49] (Figure 1B).