ALKBH5 and FTO are also (αKG) alpha-ketoglutarate-dependent enzymes, which are potentially inhibited by high accumulation of D-2-HG (D-2-hydroxyglutarate), a natural metabolite that is aberrantly produced by IDH1/2 (isocitrate dehydrogenases 1/2), proteins frequently found mutated in primary AML. Here, FTO is linked to acute myeloid leukemia.