NPM1 and acute myeloid leukemia: Loss or downregulation of HOX regulatory miRs, such as hsa-miR-204 and hsa-miR-128a, and overexpression of Homeobox (HOX) genes (specifically HOXA and HOXB) have been suggested as potential disease-specific signatures in AML patients simultaneously carrying mutations in the nucleophosmin 1 (NPM1) gene.