Loss of DKC1 or snoRNA-guided pseudouridylation impairs splicing fidelity, possibly leading to aberrant splicing of tumor suppressors or oncogenes, exon skipping, or intron retention, all known as crucial features in hematological cancers, especially in MDS with splicing factor mutations (e.g., SF3B1, SRSF2). This evidence concerns the gene SF3B1 and myelodysplastic syndrome.