IFIH1 and acute lymphoblastic leukemia: In acute lymphoblastic leukemia (ALL), especially T-ALL, elevated A → I editing has been associated with relapsed T-ALL; ADAR1 editing by p150 isoforms (cytoplasmic) attenuates dsRNA sensing and promotes leukemic survival through both MDA5-dependent and independent pathways based on the intrinsic expression of MDA5 [95].