NPM1 and acute leukemia: Quantification of the precise proportion of NPM1 protein localized to the cytoplasm of NPM1-mutated cells is challenging, and the biological relevance of how NPM1 mutant cells are prone to develop acute leukemia by acting at the chromatin level in cooperation with miR species (hsa-miR-204 and hsa-miR-128a) as potential partners remains unclear.