NFKB1 and neoplasm: By contrast, circPLCE1 encodes a small peptide that drives ubiquitin-dependent degradation of RPS3, a noncanonical cofactor of NF-κB; the resulting reduction in NF-κB transcriptional activity suppresses tumor growth and metastasis, indicating that coding circRNAs can also down-modulate proinflammatory oncogenic signaling [78].