SLC25A1 and neoplasm: SLC25A1 promotes tumor growth through a dual metabolic strategy: under nutrient-rich conditions, it exports mitochondrial citrate to the cytosol to boost acetyl-CoA production and enhance de novo synthesis of fatty acids and phospholipids, providing membrane lipids and energy for rapid proliferation; during energy stress or nutrient deprivation, it increases TCA cycle substrate supply and electron transport efficiency in mitochondria, strengthening oxidative phosphorylation to maintain ATP supply and resist stress-induced apoptosis.