LDHA and neoplasm: At the level of glycolysis and lactate metabolism, small-interfering RNA targeting lactate dehydrogenase A, delivered via cationic polymer complexes, reduces tumor-cell lactate secretion, prevents M2-like polarization of tumor-associated macrophages, and converts protective autophagy into lethal autophagy, thereby markedly enhancing the antitumor efficacy of oxaliplatin [154].