Cheng et al. demonstrated that silencing IQGAP1 via adeno-associated virus (AAV) in ApoE−/− and Ldlr−/− C57BL/6J mice on a high-fat diet alleviates atherosclerosis by suppressing mtDNA-cGAS-STING–mediated endothelial pyroptosis [94]. This evidence concerns the gene CGAS and atherosclerosis.