The cyclic GMP-AMP synthase (cGAS)–stimulator of interferon genes (STING) axis serves as a primary cytosolic DNA sensor, activating downstream TANK-binding kinase 1 (TBK1)/(Interferon Regulatory Factor 3) IRF3 and Nuclear factor-kappa B (NF-κB) pathways to induce type I interferons (IFN-I) and pro-inflammatory cytokines, thereby driving vascular inflammation, myocardial fibrosis, and remodeling [3,4]. The gene discussed is TBK1; the disease is Myocardial fibrosis.