STING1 and Hyperglycemia: Yet, cGAS–STING is of particular relevance in T2DM, since metabolic stressors (e.g., hyperglycemia, lipid overload, mitochondrial damage) trigger mitochondrial and nuclear DNA leakage, resulting in chronic cGAS-STING activation and low-grade inflammation that exacerbates vascular and myocardial injury.