Melanoma cells with high ABCB5 expression show elevated metastatic potential in vitro and in vivo, and ABCB5 mutations have been shown to promote proliferation and invasiveness capabilities in melanoma cells [12]. ABCB5 may be expressed in melanoma stem cells with a CD133+ phenotype and might mediate DOX resistance [13,14]. This evidence concerns the gene PROM1 and melanoma.