The KEGG enrichment results (Figure 1C) showed that the core targets were mainly involved in pathways related to lipid and atherosclerosis, the AGE-RAGE signaling pathway in diabetic complications, the PI3K/Akt signaling pathway, etc. Notably, the significant enrichment of the AGE-RAGE and PI3K-Akt pathways suggests that RD may alleviate diabetic wounds by mitigating hyperglycemia-induced inflammatory damage and promoting cellular survival and angiogenesis. Here, AKT1 is linked to atherosclerosis.